IMMUNOBIOLOGY IgG1 and IVIg induce inhibitory ITAM signaling through Fc RIII controlling inflammatory responses
نویسندگان
چکیده
1Inserm U699, Paris, France; 2Université Paris Diderot, Sorbonne Paris Cité, Inflamex Laboratory of Excellence, Faculté de Médecine, Site Xavier Bichat, Paris, France; 3Inserm U700, Paris, France; 4Service de Pneumologie, Assistance Publique–Hôpitaux de Paris, Hôpital Bichat, Paris, France; 5Division of Allergy and Clinical Immunology, Johns Hopkins Asthma and Allergy Center, Baltimore, MD; and 6Assistance Publique–Hôpitaux de Paris, Hôpital Bichat, Service d’Immunologie, Paris, France
منابع مشابه
IgG1 and IVIg induce inhibitory ITAM signaling through FcγRIII controlling inflammatory responses.
Intravenous immunoglobulin (IVIg) has been used in the treatment of several autoimmune and inflammatory diseases. However, its mechanism of action remains incompletely understood. Here, we investigated the possibility that IVIg induces its anti-inflammatory effects through activating Fcγ receptors bearing an immunoreceptor tyrosine-based activation motif (ITAM) in the FcRγ signaling adaptor. Re...
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Although inhibitory Fc gamma receptors have been demonstrated to promote mucosal tolerance, the role of activating Fc gamma receptors in modulating T helper type (Th)2-dependent inflammatory responses characteristic of asthma and allergies remains unclear. Here, we demonstrate that signaling via activating Fc gamma receptors in conjunction with Toll-like receptor 4 stimulation modulated cytokin...
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Rheumatoid arthritis-associated (RA-associated) inflammation is mediated through the interaction between RA IgG immune complexes and IgG Fc receptors on immune cells. Polymorphisms within the gene encoding the human IgG Fc receptor IIA (hFcγRIIA) are associated with an increased risk of developing RA. Within the hFcγRIIA intracytoplasmic domain, there are 2 conserved tyrosine residues arranged ...
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platelets in the spleen. Conclusions. The authors concluded that IVIG inhibits autoantibody-mediated thrombocytopenia by inducing inhibitory Fc RIIB receptors on macrophages. The balance of inhibitory (Fc RIIB) and activating (Fc RIII) Fc receptors is likely to be a critical factor in the regulation of macrophage phagocytosis. These results suggest that autoantibody-triggered inflammatory disea...
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platelets in the spleen. Conclusions. The authors concluded that IVIG inhibits autoantibody-mediated thrombocytopenia by inducing inhibitory Fc RIIB receptors on macrophages. The balance of inhibitory (Fc RIIB) and activating (Fc RIII) Fc receptors is likely to be a critical factor in the regulation of macrophage phagocytosis. These results suggest that autoantibody-triggered inflammatory disea...
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تاریخ انتشار 2012